Strain-dependent oxidant release in articular cartilage originates from mitochondria
نویسندگان
چکیده
منابع مشابه
Strain-rate dependent stiffness of articular cartilage in unconfined compression.
The stiffness of articular cartilage is a nonlinear function of the strain amplitude and strain rate as well as the loading history, as a consequence of the flow of interstitial water and the stiffening of the collagen fibril network. This paper presents a full investigation of the interplay between the fluid kinetics and fibril stiffening of unconfined cartilage disks by analyzing over 200 cas...
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Objective Articular cartilage as an avascular skeletal tissue possesses limited capacity to heal. On the other hand, it is believed that the regeneration capacity of each tissue is largely related to its stem cell contents. Little is known about the presence of mesenchymal stem cells in articular cartilage tissue. This subject is investigated in the present study. Materials and Methods Artic...
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Introduction: Articular cartilage is typically subjected to physiological loading at high strain rates. The mechanical response to this type of load is mainly governed by interactions among three material phases: collagen fibrils, proteoglycan matrix and water containing diffusible ions. Previous model studies, which have adopted the same constitutive laws for the fibrils and the proteoglycans,...
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ژورنال
عنوان ژورنال: Biomechanics and Modeling in Mechanobiology
سال: 2013
ISSN: 1617-7959,1617-7940
DOI: 10.1007/s10237-013-0518-8